中科院细胞与分子免疫学课程课件11.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * 1. Is responsible for the proliferation of the antigen specific cells. 2.Promotes the proliferation and differentiation of other immune cells. 3. IL-2 serves to terminate immune responses by stimulating the development and function of regulatory T cells and by potentiating apoptotic death of activated T cells by Fas pathway. 二 Interleukin – 4 1. Definition: is the major stimulus for the production of IgE antibodies and for the development of Th2 cells from na?ve CD4+ helper T cells. 2. Structure, Production, Receptors Structure: a member of the four-a–helical cytokine family. Production: CD4+ T lymphocyte of the Th2 subset, activated mast cells and basophiles. Receptor: 3. Signal : 4. Biologic Actions 1. Stimulate B cell Ig heavy chain class switching. 2. Stimulate the development of Th2 cells from na?ve CD4+ T cells and functions as an autocrine growth factor for differentiated Th2 cells. 3. Antagonizes the macrophage-activating effects of IFN-g. 三 Interleukin-5: 1.Definition: is an activator of eosinophils and serves as the link between T cell activation and eosinophilic inflammation. 2. Structure, Production, Receptors Structure: is a homodimer, with each subunit containing a four-a- helical domain. Production: by the Th2 of CD4+ T cells and by activated mast cells. Receptors: is a type I cytokine receptor. 3.Biologic Actions: Activate mature eosinophils and stimulate the growth and differentiation of eosinophils. Activated eosinophils are able to kill helminths. Express Fc receptor specific for IgE antibodies. IL-5 stimulates the proliferation of B cells and the production of IgA antibodies. 四 Interferon-g 1. Definition: the principal macrophage-activating cytokines serves critical functions in innate immunity and in adaptive cell-mediated immunity. It has some antiviral activity,but it is not a potent antiviral in