(肿瘤生物学)Therapeutic potential of monoacylglycerol lipase inhibitors.pdf

Life Sciences 92 (2013) 492–497 Contents lists available at SciVerse ScienceDirect Life Sciences jour nal homepage: /locate/lifescie Minireview Therapeutic potential of monoacylglycerol lipase inhibitors Melinda M. Mulvihill, Daniel K. Nomura ⁎ Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, CA 94720, USA a r t i c l e i n f o a b s t r a c t Article history: Marijuana and aspirin have been used for millennia to treat a wide range of maladies including pain and Received 5 May 2012 inflammation. Both cannabinoids, like marijuana, that exert anti-inflammatory action through stimulating Accepted 23 October 2012 cannabinoid receptors, and cyclooxygenase (COX) inhibitors, like aspirin, that suppress pro-inflammatory eicosanoid production have shown beneficial outcomes in mouse models of neurodegenerative diseases Keywords: and cancer. Both cannabinoids and COX inhibitors, however, have untoward effects that discourage their Monoacylglycerol lipase MAGL chronic usage, including cognitive deficits and gastrointestinal toxicity, respectively. Recent studies have un- mgll covered that the serine hydrolase monoacylglycer