(肿瘤生物学)Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer.pdf

Cancer Letters 307 (2011) 6–17 Contents lists available at ScienceDirect Cancer Letters journal homepage: /locate/canlet Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer Lin Ye a,1, Bo Zhang a,b,1, Elena G Seviour b, Kai-xiong Tao a, Xing-hua Liu a, Yan Ling a, Jian-ying Chen a,⇑, Guo-bin Wang a,⇑ a Department of General Surgery, Union Hospital affiliated to HuaZhong University of Science and Technology, WuHan 430022, China b Department of Systems Biology, Unit 950, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, United States of America a r t i c l e i n f o a b s t r a c t Article history: Objectives: Obesity has been reported to increase the risk of colorectal cancer, which may Received 16 January 2011 due to aberrant lipid metabolism. And recently findings of monoacylglycerol lipase provide Received in revised form 9 March 2011 a novel evidence in the correlation of obesity and cancer. So in this study, we investigated Accepted 11 March 2011 the effect of MAGL in regulation of tumor growth in colorectal cancer. Methods: MAGL expression in tumor tissues was estimated, and then JZL184 and siRNA were used to knockdown the expression of MAGL in colorectal cancer cells. Cell viability Keywords: and invasion were detected to estimate the influence of MAGL knocked down in vitro Colorectal cancer MAGL