(肿瘤生物学)The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress.pdf

Cell Biochem Biophys (2014) 70:33–36 DOI 10.1007/s12013-014-9899-2 REVIEW PAPER The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress Hong Qin • Zhi-hua Ruan Published online: 16 March 2014 Springer Science+Business Media New York 2014 Abstract In recent years, metabolism is talked highly onstrate a new role of MAGL in cancer progress. There is a important in cancer research, especially the lipid metabo- high expression of MAGL in many types of cancer cell lism. Researchers believe that the de novo fatty acid syn- lines [ 1]. A host of investigations have pointed that MAGL thesis plays an important role in tumor development, while control the level of FFA plays a major role in tumorigen- many studies illustrated that Endocannabinoids have anti- esis. This view is point to take all researches about MAGL tumorigenic actions, including anti-proliferation, apoptosis for cancer together, and re-recognize the function of induction, and anti-metastatic effects, MAGL as an MAGL in tumors. Finally, it is potential to find new important decomposing enzyme of both lipid metabolism molecular targets for cancer treatment. and endocannabinoids system, additionally as a part of a gene expression signature contributes to different aspects of tumourigenesis. Lipid Metabolism in Cancer Keywords Monoacylglycerol lipase (MAGL) Free fatty When Otto Warburg illustrate the ‘‘Warburg effect’’ in acid (FFA) Lipid metabolism Endocannabinoid Tumor 1920s, the metabolism in tumorigenesis become more and more popular, recently the hyperactivity of de novo fatty acid (FA) syn