多西环素联合克林霉素治疗女性生殖道支原体感染的临床疗效和安全性.docVIP

多西环素联合克林霉素治疗女性生殖道支原体感染的临床疗效和安全性 　　[摘要] 目的 研究多西环素联合克林霉素治疗女性生殖道支原体感染的临床疗效及安全性。 方法 选择2013年1月～2014年10月本院妇科收治的生殖道支原体感染患者129例为研究对象，依据治疗方法将其分为治疗组与对照组。治疗组采用多西环素口服联合克林霉素静点治疗；对照组采用单一多西环素口服治疗。观察两组治疗效果，评价其安全性。 结果 治疗组总有效率为96.92%，高于对照组的79.69%，差异有统计学意义（P0.05）。 结论 多西环素联合克林霉素治疗女性生殖道支原体感染有较好的临床疗效及安全性 [关键词] 多西环素；克林霉素；生殖道支原体感染；安全性 [中图分类号] R978.1 [文献标识码] A [文章编号] 1674-4721（2016）05（c）-0069-03 Clinical efficacy and safety evaluation of doxycycline joint clindamycin for Mycoplasma infection of female genital tract BAO Hai-yan WANG Duo ZHENG Xiang-yang Department of Gynaecology，the Second People′s Hospital of Dalian City，Dalian 116011，China [Abstract] Objective To investigate the clinical efficacy and safety evaluation of doxycycline joint clindamycin for Mycoplasma infection of female genital tract. Methods 129 cases with Mycoplasma infection of female genital tract were divided into treatment group （65 cases） and control group （64 cases） by different treatments in our hospital department of gynaeology from January 2013 to October 2014.The treatment group were given doxycycline by oral joint clindamycin by intrarenous，while the control group were given doxycycline alone.Curative effect of two groups were observed and safety were evaluated. Results The total effective rate was 96.92% in the treatment group，higher than 79.69% in the control group，the difference between the two groups was statistically significant（P0.05）. Conclusion For Mycoplasma infection of female genital tract，the treatment of doxycycline joint clindamycin has a better clinical efficacy and safety. [Key words] Doxycycline；Clindamycin；Mycoplasma infection of female genital tract；Safety 近年来，支原体感染引起的泌尿生殖道疾病发病率呈上升趋势。支原体感染可引起宫颈炎、输卵管炎、羊膜炎、自发性流产、不孕不育等[1]，与复发性流产密切相关[2]，对女性生殖健康危害极大，且与早产、低出生体重及新生儿肺疾病相关[3]。抗菌药物的不合理应用及耐药菌株的增加，使病情反复发作、病程迁延，且出现上行感染病例，如腹腔、心脏术后支原体感染[4]，给临床治疗带来困难。因此，对久治不愈反复发作的患者，应考虑是否合并支原体感染并予以积极治疗。本院采用多西环素联合克林霉素治疗女性生殖道支原体感染，效果明显 1 资料与方法 1.1 一般资料 选取本院妇科2013年1月～2014年10月收治的生殖道支原体感染患者129例，表现为外阴