异维A酸药理(国外英文资料).docVIP

异维A酸药理(国外英文资料) Oral alloxic acid treatment for common acne research progresses (total 109) Chinese medical journal, no. 43, 2008 Li xiuyu (general hospital of the Chinese peoples liberation army, Beijing 100853) Middle image classification number: R758. 73 + 3 document identification code: C article number: 1008-1070 (2008) 2002-0029-04 Isovera acid is used in acne treatment for more than 20 years, and the mechanism, dosage, treatment and adverse reactions of acne are discussed. 1 pharmacodynamics Good oral absorption of vitamin A acid, quickly absorbed by the gastrointestinal tract after oral, 2 ~ 4 hours after the peak blood levels, has A half-life of 10 ~ 20 hours, 4 - oxygen - 13 - vitamin A acid is its main metabolites. It is mainly metabolized in the liver or the wall of the intestine, with the original form and the metabolite into the hepatic circulation. The bioutilization rate is about 25 percent after orally, because it is lipid soluble, and it can be promoted immediately after meals or immediately after the meal. High rate of absorption of the plasma combined with (almost 100% combined with albumin), without changing the prototype drug from the stool, the main metabolites in urine and bile in the form of combination of eduction. In continuous medicine, 40mg/times, 2 times a day, no drug was found in the body and had an effect on enzyme metabolism after 1 month. Mechanism study Known acne pathogenesis mainly has the sebaceous glands function, hair follicle sebaceous glands catheter abnormal keratinization, the role of microbes in pilosebaceous units and four aspects of the inflammatory response. Different vitamin A acid capsule is currently only available for the pathogenesis of acne known four link, give play to the role of treatment drugs can not only control the development of inflammation, but also reduce medium and severe acne scar formation, and can make acne improved long-term [1]. Oral vitamin A acid can reduce the secretion of sebaceous gland, its