麻醉重点整理(国外英文资料).docVIP

麻醉重点整理(国外英文资料) Half of the effective (ED50) and half of the effective concentration (EC50) : the dose or concentration that can cause half (50%) of the individual to produce a certain effect. 2 treatment index (TI) : TI = LD50 / ED50 is safer, but this is not entirely reliable. Full agonist: both inner activity and affinity are strong (alpha = 1). Antagonist (antagonist) : strong affinity with receptors, but no intrinsic activity (alpha = 0). 5 rule repeats, after (4 ~ 6) 5 t1/2, the concentration of blood drug reaches steady state concentration (Css). Eliminating half-life: the amount of time needed to eliminate 50% of the drug in the body. (final half-life) Plasma half-life: a 50% reduction in plasma drug concentration. In a room model, these two things are equivalent 8 static instant half-life: the amount of time required for plasma drug concentration to drop 50% at any time in intravenous infusion. Effect room (effect level) : the role of the drug in biological effect. Plasma - effect balance: effect chamber concentration is equivalent to blood drug concentration; The concentration of the drug is proportional to the effect. The time and magnitude of the effect of the effects of the effect on the peak concentration were influenced by keo, which was inversely proportional to keo. Ke0, t1/2 keo is short, the static note after effect room drug concentrations rise faster, achieve a balance of time is short, the plasma - peak concentration is high, the drug effect appears early, the time lag is short; Small ke0, long t1/2 keo, static note after effect room drug concentration rises slowly, achieve a balance of time is long, the plasma - peak concentration is low, drug effect appeared late, long time lag. Effect room (small junction) 1. Effect room (effect). Plasma - effect balance: effect chamber concentration is equal to blood drug concentration; The concentration of the drug in the effect chamber is proportional to the effect; By monitoring the effects of drug effect