博士生课程21-固有免疫系统.pptVIP

The Epithelial Layer: The initial barrier to infection Physical barrier of the epithelial layer (toughness of barrier varies by location due to other functions: air exchange, nutrient uptake, etc.) Mucus/cilia to remove particles (lung, intestines) Acid pH of the stomach Anti-microbial peptides secreted by some epithelial cells (small intestines, small airways of lungs) Commensal bacteria (compete with pathogenic bacteria) 6. Secretory IgA (adaptive immunity) 7. Intraepithelial lymphocytes (adaptive immunity) Monocyte - blood Alveolar Mfs–lung Histiocytes – connective tissue Kupffer cells –