硫酸氯吡格雷联合辛伐他汀治疗老年高血压患者颈动脉斑块临床分析.doc

硫酸氯吡格雷联合辛伐他汀治疗老年高血压患者颈动脉斑块临床分析 　　作者：张丽侠　 作者单位：(河北大厂回族自治县中医院内科，河北 廊坊　065300) 　　【摘要】 目的：探讨比较硫酸氯吡格雷与阿司匹林分别联合辛伐他汀对老年高血压患者颈动脉斑块的疗效。方法：选取我院2008年1月～2010年治疗高血压并明确有颈动脉斑块的98例老年患者为研究对象，将其随机分为观察组和对照组，各49例，观察组采用硫酸氯吡格雷联合辛伐他汀进行治疗，对照组采用阿司匹林联合辛伐他汀进行治疗。结果：观察组治疗后6个月的颈动脉内膜中层厚度、斑块总面积及斑块积分均小于对照组，血清HDL-C高于对照组，血清LDL-C、TG、TC、血小板聚集率低于对照组(P均0.05)。结论：硫酸氯吡格雷联合辛伐他汀对老年高血压患者颈动脉斑块的影响更大，并可显著降低患者血脂。 　　【关键词】 硫酸氯吡格雷,辛伐他汀,老年高血压;颈动脉斑块 　　[ABSTRACT] Objective： To investigate the efficacy for clopidogrel and aspirin simvastatin in treatment for the carotid plaque of elderly hypertensive patients. Methods：A total of 98 elderly patients with high blood pressure and carotid artery plaque admitted from January 2008 to May 2010 were chosen. They were randomly divided into group A and group B by half. A group were treated by clopidogrel simvastatin treatment， while B group by aspirin simvastatin treatment. The carotid artery intima-media thickness， plaque block area and plaque score， serum HDL-C， LDL-C， TG， TC， and the level of platelet aggregation rate of two groups before treatment and 6 months after treatment were observed and compared. Results：The carotid artery intima-media thickness， plaque area and plaque score in the A group 6 months after treatment were significantly less than group B; The serum HDL-C in group A was significantly higher than group B; The serum LDL-C， TG， TC， platelet aggregation rate in the group A were significantly lower than group B ( all P0.05).Conclusions：Clopidogrel and aspirin simvastatin can lower blood lipid and is effective on treating carotid plaque of elderly hypertensive patients is effective on treating carotid plaque of elderly hypertensive patients. 　　[KEY WORDS] Clopidogrel; Simvastatin; Elderly hypertension; Carotid artery plaque 　　老年高血压患者中较多伴有颈动脉斑块，如能改善患者的这些指标则表明患者的疾病情况得到有效改善[1]。本文就硫酸氯吡格雷与阿司匹林联合辛伐他汀治疗老年高血压患者颈动脉斑块的疗效进行比较，现报道如下。 　　1　资料与方法 　　1.1　一般资料 　　选取我院2008年1月～2010年5月治疗高血压并明确有颈动脉斑块的98例老年患者为研究对象，随机分为观察组和对照组，各49例。观察组：患者49例，男性29例，女性20例，年龄