免疫移植2.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Generation of cytotoxic T lymphocytes Another consequence of the MHC antigen and T cell interaction is the induction of cytotoxic T?lymphocytes. When T?lymphocytes are cultured in the presence of allogeneic lymphocytes, in addition to undergoing mitosis (MLR), they also become cytotoxic to cells of the type that stimulated MLR (Figure 3). Thus, T?lymphocytes of x haplotype cultured over 5?7 days with B lymphocytes of y haplotype will undergo mitosis and the surviving T?lymphocytes become cytotoxic to cells of the y haplotype. The induction of mitosis in MLR requires disparity of only class?II antigens whereas the induction of cytotoxic T?lymphocytes (CTL) requires disparity of both class?I and class?II antigens. However, once cytotoxic cells have been induced, the effector cytotoxic cells recognize only class?I antigens to cause cytotoxicity. * * * * Generation of cytotoxic T lymphocytes Another consequence of the MHC antigen and T cell interaction is the induction of cytotoxic T?lymphocytes. When T?lymphocytes are cultured in the presence of allogeneic lymphocytes, in addition to undergoing mitosis (MLR), they also become cytotoxic to cells of the type that stimulated MLR (Figure 3). Thus, T?lymphocytes of x haplotype cultured over 5?7 days with B lymphocytes of y haplotype will undergo mitosis and the surviving T?lymphocytes become cytotoxic to cells of the y haplotype. The induction of mitosis in MLR requires disparity of only class?II antigens whereas the induction of cytotoxic T?lymphocytes (CTL) requires disparity of both class?I and class?II antigens. However, once cytotoxic cells have been induced, the effector cytotoxic cells recognize only class?I antigens to cause cytotoxicity. * * * * * * * * * * * * * * * 2、慢性GVHD 一个或多个器官的纤维化和萎缩 最终可导致所累及器官的功能丧失 Early, chronic GVHD with widespread, almost confluent hyperpigmented lichenoid papules and toxic epidermal necrosis-like appea