三十三、应激性高血压、心律掉常的心理基础(国外英文资料).docVIP

三十三、应激性高血压、心律失常的生理基础(国外英文资料) This inhibiting effect in spontaneous hypertensive rats significantly lowers blood pressure, so GABA may be one of the causes of hypertension in this type of rat. Literature reports central gamma aminobutyric acid (GABA) has obvious inhibitory effect on the sympathetic activity, inhibits excitability, high blood pressure, and cardiac arrhythmias, this role by GABA receptor mediated A. Gu Yunhui etc. (1989) reported that excited ventrolateral medulla oblongata the rear area of rats (cVLM) A1 of norepinephrine in the fiber, by alpha and beta adrenergic receptor function in the rVLM GABA interneurons, can by GABA interneurons inhibition effect to the rVLM sympathetic neuron activity, cause step-down reaction. (4) rVLM - adrenaline In rVLM trace injection of sugar, salt, cortical hormone can cause rat blood pressure, heart rate, if the injection of mineralocorticoid antagonist RU38486 or spiral lactone in bilateral rVLM can cause normal rats blood pressure drops, the heart rate slows, reducing defensive pressure response. It is indicated that the adrenocorticoid hormone is a positive regulation of the central cardioascular retentivity and normal blood pressure. The strengthening of the adrenal cortex in rVLM cardioascular activity is an important link in the pathogenesis of stress hypertension. This mechanism may be through rapid membrane effect of steroid hormones, M on the rVLM cardiovascular neuron membrane receptors and adjusted calcium channel, result in abnormal increase on cholinergic activity, in the process, NO system may also be involved in. (5) rVLM - blood vessel booster In 1993, Gomeg et al. Reported that the hypothalamus ventricle (PVN) vasopressin neuron and rVLM were projected. In the course of acute loss of blood, it can increase the activity of sympathetic tension by activating the angiotensin V1 receptor in the rVLM region. Literature on electrical stimulation of the periaqueductal gray dorsal defense reaction zone (dPAG)