血小板削减的启事(国外英文资料).docVIP

血小板减少的原因(国外英文资料) [thrombocytopenia] Human blood platelet, normal person per cubic millimeter contains about 10 ~ 300000 platelets in the blood, its average life expectancy for 8 to 12 days, due to various reasons lead to lower limit is lower than the reference value, the platelet count results is thrombocytopenia. Causes of thrombocytopenia: Acute type ITP occurs in the recovery of viral infection or upper respiratory infection, such as rubella, measles, chicken pox, and parotid gland cancer. The serum of the patient has high antivirus antibody, the platelet surface is associated with an increased antibody, which is thought to be caused by virus antigen. Pathogenesis may be antigen-antibody complexes, including virus antigen and platelet fc receptor or virus antigen of autoantibodies cross reaction with the platelet membrane and damage of platelets, and cleared by phagocytes. Chronic ITP premorbid premorbid infection is caused by a change in the antigens of the platelet structure. Eighty to ninety percent of the medical records have platelet surface related antibodies, 95% of which are PalgG, two-thirds PalgG and PalgM, and the minority are PalgA and pac. The antibody directly ACTS on the glycoprotein on the platelet membrane, a small number of functions and the Gbib complex, which make the platelet life shorter and the function changes. Its content is negatively correlated with platelet life, and the spleen is the main site of platelet antibody production. ? Possible causes of thrombocytopenia: A drug that causes the bone marrow to regenerate lower or lower blood cells. Chemicals and drugs that cause the bone marrow to be low in a given dose: Benzene, xylene, etc. A: such as nitrogen mustard, cyclophosphamide, and phenylpropionate. Antimetabolism-drugs such as cytidine, mercaptopurine, etc. Anti-cancer antibiotics: such as tetracycin and amycin. Other: organic arsenic, etc. 2. The drug can cause bone marrow regeneration barrier or low: such as chloramphenicol, sul