胰岛素信号转导_昆虫发育及老化.pdfVIP

( ) 2009 46 4 昆虫知识 　Chinese Bulletin of Entomology 　 ·50 1 · 科技前沿 胰岛素信号转导 、昆虫发育与老化 1 2 顾世红 　陈建国 ( 1. 台中市自然科学博物馆动物学组 　台湾 　40419 ; 2 . 北京大学生命科学院细胞生物学系 　北京 　100871) Insulin signaling , insect development and ageing. GU ShiHong1 , CHEN JianGuo2 ( 1. Dep artment of Zoology , N ational M useum of N atural Science , 1 Kuan Chien Road , Taichung 40419 , Taiwan , China ; 2 . Dep artment of Cell B iology , College of L fi e Science , B eij ing University ,Beijing 　100871 , China) Abstract 　The investigation of insulin and its signaling is one of the hot topics in modern biology. It has become apparent that there exists a evolutionary conservation of insulin signaling mechanism from worms , flies , mice and human . The study of insect insulin began in B ombyx mori . J apanese researchers discovered the bombyxin , an insulin - like peptide which showed high similarity with human insulin in amino acid when they investigated the prothoracictropic hormone ( PTTH) in 1980 . However , the exact role of bombyxin is still not very clear . In Drosop hila melanogaster , molecular genetic study showed that insulin signaling plays an important role in regulating insect growth , development , and ageing. The studies on D . melanogaster during recent years showed that alternation in insulin signaling through molecular genetic engineering , specifically in the prothoracic glands leads to altered insect molting and metamorphosis. Our study on B . mori showed that bovine