针灸镇痛机制.pdfVIP

a r t I C l e S Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture 1,4 1,4 1,4 1 1 1 1 Nanna Goldman , Michael Chen , Takumi Fujita , Qiwu Xu , Weiguo Peng , Wei Liu , Tina K Jensen , 1 1 1 2 3 1 Yong Pei , Fushun Wang , Xiaoning Han , Jiang-Fan Chen , Jurgen Schnermann , Takahiro Takano , 1 1 1 Lane Bekar , Kim Tieu Maiken Nedergaard Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties . d in reconciling its principles with evidence-based medicine. We found that adenosine, a neuromodulator with anti-nociceptive e v properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor r e s expression. Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture. Inhibition of e r enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti- s t nociceptive effect. These observations indicate that adenosine mediates the effects of acupuncture and that interfering with h g adenosine metabolism may prolong the clinical benefit of acupuncture. i r l l A Acupuncture is a procedure in which fine needles are inserted into to purinergic receptors, including P2X and P2Y r