抗抑郁药历史和研究进展.pdfVIP

2009 2 28 2 135 特约稿 1 2 童晓欣 , 童萼塘 ( 1. , 518036; 2. , 430022) [ ] 自 20世纪 50年代以来, 抗抑郁药研究进展迅速该文对抗抑郁药的历史分类化 结构分类和作用机 制分类等进行了简要介绍, 并对新型抗抑郁药选择性 5羟色胺 ( 5HT) 再摄取抑制药5HT 再吸收促进药选择性 5HT 与去甲肾上腺素 ( NA ) 再摄取抑制药去甲肾上腺素能和特异性 5HT 能抑制药去甲肾上腺素能和多巴胺能摄取抑制 药新型可逆性单胺氧化酶抑制药(MAO I)新三环类抗抑郁药天然与中草药抗抑郁药研究进展进行了较详细介绍 [ ] 抗抑郁药; 抑郁症; 5羟色胺再摄取抑制药, 选择性; 5羟色胺和去甲肾上腺素再摄取抑制药, 选择性; 单 胺氧化酶抑制药, 可逆性 [ ] R971. 4 [] A [ ] 2009) TheHistory andDevelopmentofAntidepressants 1 2 TONG X iaoxi , TONG Eta g ( 1. D epartment of N eurology, Shenzhen H osp ital of Beijing University, Shenzhen 518036, China; 2. D epartment of N eurology, Union H osp ital Aff iliated ith the Tongj i M edical College, H uazhong University of Science and Technology, Wuhan 430022, China) ABSTRACT Objective S i ce the seco d half of the 20th ce tury, there has bee rap id developm e t i the research of a tidepressa ts. Th is paper prese ts a co cise i troductio of their historica,l classificatio of chem ical structure a d actio m echa ism. It also gives a com prehe sive i troductio to the research developm e t of ew a tipressa ts, i cludi g selective seroto i reuptake i h ibitors ( SSRI ) , seroto i reuptake accelera t, selective seroto i a d orep i ephri e reuptake i hibitors ( SNRI), orep i ephri e a d special seroto i a tidressa t ( N aSSA ), orepi ephri e a d dopam i e reuptake i hibitors ( NDR Is), ew reversib le m o oam i e oxidase i h ib itor, ew tricyclic, ature a d herbal a tipressa ts. KEY ORDS A tidepressa ts; Depress io ; SSRI; SNR I; Revers ibleMAO I , ), (MAO) [ 2] , , 20 20 50 , (TCA )