曼尼希碱及曼尼希碱型前药的研究现状.pdf

25 5 河 北 工 业 科 技 Vol. 25, No . 5 2008 9 H ebei Journal of Industrial Science and Technology Se t. 2008 : 1008-1534( 2008) 05-0315- 03 , , ( 河北医科大学药学院, 河北石家庄 050017) : 为探讨曼尼希碱及曼尼希碱型前药的研究现状, 系统 阅了近几年曼尼希碱及曼尼希碱型 前药在医药和生物碱合成中的作用等文献, 总结归纳出曼尼希碱及曼尼希碱型前药具有某些活性, 能改善药物的理化性质, 指出曼尼希碱及曼尼希碱型前药具有广泛的应用价值和经济价值 : 曼尼希碱; 曼尼希碱型前药; 医药; 合成 : R914; O611 : A Present research status of M annich bases and M annich base- rodrugs WANG Shu-yue, WANG Xiao-feng, FAN Shu-yan ( School of Pharmaceutical Science, H ebei Medical University , Shijiazhuang H ebei 050017, China) Abstract: Discussion of resent research status of Mannich bases and Mannich base- rodrugs is based on consulting the effect of the Mannich bases and M annich base- rodrugs on synthesis of medicine and alkaloids re orted in lit eratures, and the summa- ry and induct ion from them indicate that M annich bases and Mannich base- rodrugs have some avt ivities and can im rove the hysical and chemical ro erties of the drugs. M annich bases and M annich base- rodrugs ossess extensive a lication value and economical value. Key words: Mannich bases; M annich base- rodrugs; medicine; synthesis , , N- [ 1] 1, 2, 4- , [ 2] [ 3] 1, 2, 4- 1 [ 4] , , , Ka, , [ 5, 6] [ 6] , , 3 - 2 - 2 , 2 @ 10 , 4 @ 10 , 8 @ , , ; 10- 2 , 10@ 10- 2 mol/ L,