打针用羧苄西林钠仿单(国外英文资料).docVIP

注射用羧苄西林钠说明书(国外英文资料) Injected with sodium benzyliin sodium 【 drug name 】 Generic name: injected with carboxybenzillin sodium Carbenicillin Sodium for Injection Chinese pinyin: Zhusheyong Suobian Xilinna 【 ingredients 】 sodium benzyliin sodium Chemical name [6 s - (alpha 2, 5 alpha, beta)] - [(carboxy phenyl ethyl) amino] - 3, 3 - dimethyl - 7-4 - sulfur impurity oxygen generation - - 1 - nitrogen mixed double loop [3.2.0] heptane - 2 - formic acid disodium salt Molecular formula C17H16N2Na2O6S The molecular weight of 422.4 【 properties 】 this product is white crystalline powder. 【 pharmacological toxicology 】 this product is a broad-spectrum antibiotic of penicillin, by inhibiting the synthesis of bacterial cell wall. For e. coli, proteus, enterobacter, folic acid bacteria genera, salmonella and shigella genus enterobacteriaceae bacteria, and pseudomonas aeruginosa, h. influenzae, neisseria bacteria genera, and other gram-negative bacteria have antibacterial effect. Antibacterial activity of staphylococcus hemolytic streptococcus, streptococcus pneumoniae, and staphylococcus aureus without penicillin. Many anaerobic bacteria such as fragile bacillus and clostridium difficile are also sensitive to the product. [pharmacodynamics] intramuscular injection of 1g to the peak of the blood drug peak (Cmax) at 34.8 mg/L, and the blood drug concentration of 10mg/L after 4 hours. The blood drug concentration of 15 minutes and 2 hours of intravenous injection was 300mg/L and 125mg/L respectively. After the injection of 100mg/Kg, the blood pressure peak (Cmax) can reach 147mg/L. The distribution volume of this product (Vd) is 0.18 L/kg, and the serum protein binding rate is about 50%. This product is difficult to through the normal blood brain barrier, but pneumococcal meningitis in children with intravenous drip every 6 hours after the 69-103 mg/Kg of this product, 2 solstice day 17 cerebrospinal fluid in the drug concentration of 2.3 ~ 24.5 mg/L. About 2 percent of the metabol