第6章 DOI 10.1080=03610730490251513 Age-Related Changes in the Spontaneous Motor Rhythms of the S.pdfVIP

Experimental Aging Research, 30:113–127, 2004 Copyright # Taylor Francis Inc. ISSN: 0361-073X print/1096-4657 online DOI: 10.1080=03610730490251513 Age-Related Changes in the Spontaneous Motor Rhythms of the Senescence-Accelerated Mouse (SAMP8) J. Devin McAuley, Jonathan P. Miller, and Kevin C. H. Pang Center for Neuroscience, Mind, and Behavior, Department of Psychology, Bowling Green State University, Bowling Green, Ohio, USA The present study examined the effect of age on the spontaneous motor rhythms of mice during wheel running. The spontaneous motor tempo (SMT) of wheel running was measured for the P8 strain of the senescence-accelerated mouse (SAMP8) by recording the sequence of time intervals (measured in milliseconds) for successive revolutions of a run-wheel over the course of 16 days. Analyses of the distribution of interrevolution intervals of 2-, 7-, and 12-month-old SAMP8 revealed an age-related slowing of wheel running and a corresponding increase in variability consistent with Weber’s law. All three age groups also demonstrated a practice effect over the course of testing best described by a power law. These findings provide evidence of age-related changes in the spontaneous motor rhythms of the SAMP8 that occur as early as 7 months of age. The results are consistent with age-related changes in human subjects and suggest that spontaneous wheel-running behavior in rodents may be a good model for studying SMT. Received 11 November 2001; accepted 7 April 2003. The authors thank Z. Michael Nagy and James Flood for donating the SAMP8 in this study. The authors also wish to express their gratitude to two anonymous reviews for their comments on an earlier version of this manuscript and to Kelli Rider for