家兔心肌梗死慢性期梗死周边区交感神经重构与电重构地相关研究.pdfVIP

1016 2006 11 34 11 Chin J Cardiol, November2006, Vol. 34 No. 11 鲁志兵 江洪 余英 赵冬冬 雷汉东 王腾 黄从新 ! () ( 20), 108 (TD ) TD TD ( TD ) 43 ( GAP43)(TH) 18, 10 GAP43 TH (P 005) GAP43 TH TD TD TD (P 001),(P = 007, P= 009) ! ; ; R elationship betw een sympa thetic rem odeling and electrica l remodeling at infracted border zone of rabbit w ith chronic myocardia l infarction LU Zhibing, JIANG H ong, YU Ying, ZHAO Dongdong, LEI H andong, WANG Teng, HUANG Congxin Depart ent of Cardiology, Ren in H osp ital, Wuhan University, Wuhan 430060, China Corresponding author: JIANG H ong, E ail: hong_j _wur @ 163co Abstract! Objective To investigate the relationship between sympathetic remodeling and electrical remodeling at the infracted border zone ( IBZ) of rabbitw ith chronicmyocardial infarction (M I) M ethods Thirty rabbitswere random ly assigned into wt o groups: M I group ( n = 20): ligation of the anterior descending coronary; sham operation ( SO) group ( n= 10): without conorary ligation Eightweeks after surgery, transmuraldispersion of repolarization ( TD ) at baseline, during sympathetic nerve stmi ulation, TD change ( TD ) during sympathetic nerve stmi ulation and ventricular fibrillation threshold (VFT ) weremeasured at the IBZ inM I group and corresponding zone in SO group The distribution and densities of growth associated protein 43 (GAP43) and tyrosine hydroxylase (TH) positive nerves in ventriclewere also detectedw ith mi munohistochem ical techniquesResults Eighteen rabbits in theM I group and 10 in the SO group survived to the end of the study The densities of GAP43 and TH at the IBZ in the M I group were significantly higher than that at the corresponding zone in the SO group ( bothP 005) The densities of GAP43 and TH inM I rabbits positively correlated with TD at baseline, TD or TD during sympathetic nerve s