无催化剂-聚乙二醇.pdfVIP

Tetrahedron Letters 55 (2014) 2977–2981 Contents lists available at ScienceDirect Tetrahedron Letters journal homepage: /locate/tetlet Catalyst-free, ethylene glycol promoted one-pot three component synthesis of 3-amino alkylated indoles via Mannich-type reaction U. Chinna Rajesh, Rohit Kholiya, V. Satya Pavan, Diwan S. Rawat ⇑ Department of Chemistry, University of Delhi, Delhi 110007, India a r t i c l e i n f o a b s t r a c t Article history: A highly efficient and sustainable approach for the multi-component synthesis of biologically important Received 31 January 2014 3-amino alkylated indoles has been investigated via Mannich-type reaction under catalyst-free, ethylene Revised 24 March 2014 glycol as a recyclable promoting medium. The wide applicability of the present method was examined Accepted 25 March 2014 with various substrates viz substituted aldehydes, indoles and secondary amines. This method will be Available online 3 April 2014 useful for a large scale synthesis of 3-amino alkylated indoles without the use of column chromatogra- Dedicated to Professor Richard A. Gibbs phy. The present method provides higher environmental compatibility and sustainability factors such (1962–2014) as smaller E-factor (0.433) and higher atom-economy (AE = 93.3%). 2014 Elsevier Ltd. All rights reserved. Keywords: Multi-component reactions E-fa