自身免疫性胰腺炎临床的研究进展.pdf

@@[10]VaramballyS,LaxmanB,MehraR,etal. Golgiprotein lularcarcinomaofdiagnosisinahepatitisP-endemicAsian GOLM1isatissueandurinebiomarkerofprostatecancer[J]. population[J].MedOncol,2010,27:339-345. Neoplasia,2008,10:1285-1294. @@[13]LiX,WuK,FanD.SerumGolgiphosphoprotein2level:a @@[11]YileiMao,HuayuYang,HaifengXu,etal.Golgiprotein73 bettermarkerthanalpha-fetoproteinfordiagnosingearlyhepa (GOLPH2)isavaluableserummarkerforhepatocellularcar tocellulararcinoma[J].Hepatology,2009,50:1602-1609. cinoma[J].Gut,2010,59:1687-1693. @@[14]张祖平，张德忠，吴耀震.血清GP73联合AFP对PHC的早 @@[12]Jin-songHu,De-wuWu,ShuoLiang,etal.GP73,aresident 期诊断价值探讨[J].放射免疫学杂志，2010，23:205-206. Golgiglycoprotein,issensibilityandspecificityforhepatocel 2010-01-19 自身免疫性胰腺炎临床研究进展 辛磊 高阳 李兆申 [提要]近年来，自身免疫性胰腺炎(AIP)研究逐渐进 展。AIP是由自身免疫机制介导的，以淋巴细胞、浆细胞浸 润伴有胰腺纤维化及功能障碍为特征的特殊的慢性胰腺炎， 可累及胆管、涎腺、肾等胰外器官。常见的临床表现包括梗 阻性黄疸、腹痛、体重减轻等，类似于胰腺癌。本病采用类固 醇类药物治疗效果显著。目前，各国的AIP诊断标准尚未 达成一致。对其病理学分型、影像学表现、血清学标志、活检 技术均有各种新进展，而AIP与胰腺癌的鉴别诊断则是研 究热点。 自身免疫性胰腺炎；诊断标准；鉴别诊断 Advancesinclinicalresearchonautoimmunepancreatitis XIN LeiGAO YangLIZhao-shen DepartmentofGastroen terology,ShanghaiChanghaiHospital,SecondMilitary MedicalUniversity,200433,Shanghai,P.R.China [Abstract] Inrecentyears,researchonautoimmune pancreatitis(AIP)hasgainedsignificantprogress.AIPisa specialtypeofchronicpancreatitiswhichismediatedbyan autoimmunemechanism.Itischaracterizedbytheinfiltration oflymphocytesandplasmacellsleadingtopancreaticfibrosis anddysfunction. AIPcanaffectthebileducts, salivary glands,kidneysandotherorgansoutsidethepancreas.The commonmanifestationsincludeobstructivejaundice,abdom inalpain,andweightloss,whicharesimilartopancreatic cancer.Steroidtherapyisofsignificanteffect.Thereisno consensusnowadaysonthediagnosticcriteriaofAIPacross theworld.Therearemanystudiesonthepathologicalsub typ