正交试验优选白芨胶的提取工艺.PDFVIP

正交试验优选白芨胶的提取工艺 1＊ 1 2# 周忠东 ，陈劲柏 ，王建平 （1.绍兴市中医院，浙江绍兴 312000；2.浙江省中医院，杭州 310006） 中图分类号 R283；R624 文献标志码 A 文章编号 1001-0408（2014）23-2141-02 DOI 10.6039/j.issn. 1001-0408.2014.23.11 摘 要 目的：优选白芨胶的提取工艺。方法：以乙醇浸泡浓度、加热回流时间、加热回流温度为因素，以白芨胶收率为指标进行 4 L （3）正交试验。结果：白芨胶的最佳提取工艺为100ml 70％乙醇溶液浸泡4h ，80 ℃加热8h ，白芨胶收率为33.7％。结论：该提9 取工艺稳定、可行，避免了有机溶剂的引入，可为工业生产提供依据。 关键词 白芨胶；生物黏附给药系统；正交试验 Optimization of Extraction Technology of Bletilla striata Gum Gastric Mucoadhesive Powder by Orthogonal Test 1 1 2 ZHOU Zhong-dong ，CHEN Jin-bai ，WANG Jian-ping （1.Shaoxing Hospital of TCM ，Zhejiang Shaoxing 312000，China ；2.Zhejiang Provinicial Hospital of TCM ，Hangzhou 310006，China ） ABSTRACT OBJECTIVE ：To optimize the extraction technology of Bletilla striata gum gastric mucoadhesive powder of Coryda- 4 lis turtschaninovii and Melia toosendan. METHODS ：The preparation technology of B. striata was optimized by L （3）orthogonal 9 technology with ethanol soaking concentration ，heating reflux duration and heating reflux temperature as factors using the yield of B. striata gum as index. RESULTS ：The optimal preparation technology was as follows ：soaking in 100ml 70％ethanol for 4 h ， at 80 ℃，heating for 8h ，yield of B. striata 33.7％. CONCLUSIONS ：The preparation technology of B. striata gum gastric mucoad- hesive powder is scientific to avoid the introduction of organic solvent ，and the trial provides reference for industrial production. KEYWORDS Bletilla striata ；Bioadhesive drug delivery system ；Orthogonal test 胃炎、胃溃疡及十二指肠溃疡是我国的常见多发病。中 失