一项随机临床试验表明：孕期第三个月进行失眠治疗可减少产后抑郁症状.pdf

Psychiatry Research 210 (2013) 901–905 Contents lists available at ScienceDirect Psychiatry Research journal homepage: /locate/psychres Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial Habibolah Khazaie a, Mohammad Rasoul Ghadami a,n, David C. Knight b, Farnoosh Emamian a, Masoud Tahmasian a,c a Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran b Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA c TUM-Neuroimaging center (TUM-NIC), Klinikum rechts der Isar, Technische Universität München, Munich, Germany a r t i c l e i n f o a b s t r a c t Article history: Mental health is an important medical issue in perinatal care, and there is increasing evidence that Received 31 March 2013 insomnia during pregnancy is associated with postpartum depression (PPD). Therefore, the present study Received in revised form evaluated the effect of insomnia treatment during the third trimester of pregnancy on PPD symptoms. 25 June 2013 Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or Accepted 11 August 2013 placebo treatment. Sleep quality was measured by actigraphy at baseline, and after 2 and 6 weeks of treatment. In addition, depression was assessed 2 and 6 weeks after delivery. Trazodone and Key