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熊去氧胆酸治疗药物性肝损伤开放对照临床试验
278 Chinese Hepatology, Aug. 2009, Vol. 14, No. 4
论 著
倪鎏达 谢青 李捍卫 韩文科 徐伟民 王琳 谢敬东 许昕 陈晓蓉 徐国光 陈成伟
(UDCA) ( DILI) 28 8 DILI
2 ,144 UDCA (7 50 mg/ d) ( A ) ,14 4 ( B ) ,
2 A B( 0. 00 6 2
0. 03 4 4) ; DBil T B ( 0. 00 1 6 0. 00 7 3) ,( B ) TBilDBil
(0 .002 6 0 .0 00 2) ;TBilDBil T
( 0 .00 0 2 0 .0 00 0 0 .0 00 8) UDCA DILI,
;
Ursodeoxycholic acid in the treatment of druginduced liver injury : an open controlled clinical trial N I L iud a,
X I E Q ing , L I H anw e i, H A N Wenke, X U We imin , WA N G L in, X I E J i ngdo ng , X UX in , CH E N X iaor ong , X U
Guog uang , CH EN Chengwe i . N anj ng M ili ary L iv er D isease R esear ch Cen er , Shang hai 2 00235, Ch ina
Corresponding author:CHEN Chengwei, Email:ccw2 @ 163. com
Abstract Objective To investigate the efficacy and safety of ursodeoxycholic acid ( UDCA) in the treatment of
druginduced liver injury ( DILI) . Methods Two hundred and eighty eight cases of clinically diagnosed DILI patients
were divided into two groups: treatment group with liverprotecting and transaminaselowering treatment together with
UDCA( 750 mg/d) treatment ( group A) , the control without UDCA ( group B) . Comparison between two groups was
analyzed in clinical signs, symptoms and biochemical indicators of liver function. Results In the clinical signs and
symptoms, such as fatigue, vomiting, group A is more improved than in group B significantly( 0. 0 06 2 and 0. 023 4 ,
respectively) . In the biochemical aspects of liver function DBil, T , group A was significantly better than that in group
B (0 . 0 01 6 and 0. 00 7 3, respectively) . There was significant difference in T Bil, DBil and T before and after
treatment in patients with cholestasis and DILI ( 0 .0
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