抗肿瘤新靶点黏着斑激酶FAK及其抑制剂研究进展.pdf

[9] GILLS J J, DENNIS P A. The development of 3-Substituted indole inhibitors against francisella tularensis phosphatidylinositol ether lipid analogues as inhibitors of the FabI identified by structure-based virtual screening [J]. J Med serine/threonine kinase, Akt [J]. Expert Opin Invest Drugs, Chem, 2013, 56(5): 2059-2073. 2004, 13(7): 787-797. [22] LIN H, YAMASHITA D S, XIE R, et al. Tetrasubstituted [10] QIAO L, NAN F, KUNKEL M, et al. 3-Deoxy-D-myo-inositol pyridines as potent and selective Akt inhibitors: reduced 1-phosphate, 1-phosphonate, and ether lipid analogues as CYP450 and hERG inhibition of aminopyridines [J]. Bioorg inhibitors of phosphatidylinositol-3-kinase signaling and Med Chem Lett, 2010, 20(2): 648-688. cancer cell growth [J]. J Med Chem, 1998, 41(18): 3303-3306. [23] BARNETT S F, DEFEO-JONES D, FU S, et al. Identification [11] PAL K S, RECKAMP K, YU H, et al. Akt inhibitors in and characterization of pleckstrin homology domain dependent clinical development for the treatment of cancer [J]. Expert and isozyme specific Akt inhibitors [J]. Biochem J, 2004, Opin Investig Drugs, 2010, 19(11): 1355-1366. 385(Pt 2): 399-408. [12] MOSES S A, ALI M A, ZUOHE S, et al. In vitro and in vivo [24] LINDSLEY C W, ZHAO Z, DUGGAN M E, et al. Allosteric activity of novel small-molecule inhibitors targeting the Akt (PKB) kinase inhibitors. Discovery and SAR of isozyme pleckstrin homology