利妥昔单抗的罕见不良反应.pdf

药物不良反应杂志 2010年 10月第 12卷第 5期 ADRJ, Oc tober 2010, Vol 12. N o. 5 # 321# # # 利妥昔单抗的罕见不良反应 * 陈净 李剑 (, 100730) 利妥昔单抗是 一种人 /鼠嵌合型抗 C 20单克隆抗体,主要应用于非霍奇金淋巴 的治疗利妥昔单抗的常见不良反 应为急性输液反应, 其他严重不良反应罕见本文概述了利妥昔单抗相关的罕见不良反应如急性呼吸窘迫综合征弥漫性肺 泡出血心律失常心源性猝死慢性心功能不全进行性多灶性白质脑病肿 溶解综合征细胞因子释放综合征等, 以及不 良反应可能的发病机制临床表现和处理措施, 旨在为临床安全应用利妥昔单抗提供参考 利妥昔单抗; 不良反应; 罕见不良反应 : R 979. 19 : A : 1008-5734( 2010) 5-0321-04 R ituximab-induced rare adverse reactions Chen Jing, LiJian (D ep ar tm ent of H ema to logy, P ek ng Un on M ed cal Co lleg eH osp tal, Ch neseA cademy of M ed cal Sc ences Pek ng Un on M ed cal C olleg e, B ej ng 100730, Ch na ) ABSTRACT R ituxmi ab is a human/mouse chmi eric anti-C 20 monoclonal antibody mainly used in the treatment ofnon-Hodgkin. s lymphomas. The most common rituxmi ab-caused adverse reaction is acute infusion-related reactions and serious adverse reactions are rare. This article review s the ritux mi ab-induced rare adverse reactions, such as acute respiratory distress syndrome, diffuse alveolar hemorrhage, cardiac arrhythm ia, sudden cardiac death, chronic heart failure, progressivemultifocal leukoencephalopathy, tumor lysis syndrome, and cytokine release syndrome, as well as the possible pathogenesis, clinical features, and the management in order to provide references for safe rituxmi ab use in clinical practice. KEY WORDS rituxmi ab; adverse reactions; rare adverse reactions ( rituxmi ab) / , C 20, 95% B , C 20 B [ 1] 3 : ¹; º C 20, /; » ( C C)(A CC) 1. 1 超急性肺部病变 B, B ( acute respiratory distress syndrome, AR S)AR S 1 ,, , ,