氟哌噻吨美利曲辛片致不良反应文献分析_陈崇泽.pdf

Drug Evaluation Research 第 36 卷 第 5 期 2013 年 10 月 - 397 - 氟哌噻吨美利曲辛片致不良反应文献分析 陈崇泽 福建省长乐市医院 药剂科，福建 长乐 350200 摘 要：目的 探讨氟哌噻吨美利曲辛片致不良反应的一般规律与特点。方法 检索 2000 年 1 月—2013 年 3 月国内医药期 刊报道的氟哌噻吨美利曲辛片所致不良反应案例，并进行统计分析。结果 氟哌噻吨美利曲辛片致不良反应在老年患者发生 率较高，多在用药 1 周后发生。不良反应累及多个系统–器官，临床表现复杂多样，主要表现为泌尿系统损害和全身性损害， 严重者可出现死亡。结论 临床上应重视氟哌噻吨美利曲辛片的不良反应，坚持合理用药。 关键词：氟哌噻吨美利曲辛片；黛力新；药物不良反应；泌尿系统损害；全身性损害 中图分类号：R994.1 文献标志码：A 文章编号：1674 - 6376 (2013) 05 - 0397 - 04 DOI: 10.7501/j.issn.1674-6376.2013.05.019 Literature analysis on adverse drug reactions induced by Flupentixol and Melitracen Tablets CHEN Chong-ze Department of Pharmacy, Fujian Changle Hospital, Changle 350200, China Abstract: Objective To investigate the general rules and characteristics of adverse drug reactions (ADR) induced by Flupentixol and Melitracen Tablets. Methods To collecte the characteristics and related factors of ADR induced by Flupentixol and Melitracen Tablets reported in domestic medical journals during January, 2000—March, 2013 and analyze statistically. Results Flupentixol and Melitracen Tablets caused ADR in aging patients with a higher incidence of more than 1 week after treatment. ADR involving multiple systems- organs, clinical manifestations of complex and diverse, mainly for the urinary system damage and systemic damage, there may be serious death. Conclusion The clinical attention should be paid to Flupentixol and Melitracen Tablets ADR, adhere to the rational use of drugs. Key words: Flupentixol and Melitracen Tablets; Deanxit; adverse drug reactions; urinary system damage; systemic damage 氟哌噻吨美利曲辛片商品名称为黛力新，是复 1 资料与方法 方制剂，其有效成分是盐酸氟哌噻吨和盐酸美利曲 1.1 资料来源 辛。氟哌噻吨是一种噻吨类神经阻滞剂，小剂量具 检索 CNKI 中国期刊全文数据库2000 年 1 月— 有抗焦虑和抗抑郁作用。美利曲辛是一种双相抗抑 2013 年3 月国内公开发行的医药期刊上有关氟哌噻 郁剂，低剂量应用时，具有兴奋特性，但镇静作用