MCT动物毒理实验.pdf

FUNDAMENTAL AND APPUHD TOXICOLOGY 40 , 1 8 5 - 1 9 0 ( 1 9 9 7 ) ARTICLE NO FA97237 8 Developmental Toxicity Study in Rats and Rabbits Administered an Emulsion Containing Medium Chain Triglycerides as an Alternative Caloric Source Susan Henwood, * Daniel Wilson, ! Randy White, ! and Susan Trimbot *Coming Hazleton Inc., Madison, Wisconsin 53527; ^Baxter Healthcare Corporation, Round Lake, Illinois 60073-0490; and XClintec Nutrition Co., Deerfield Illinois 60015-0760 Received July 19, 1996; accepted September 11 , 1997 (MCT) to long chain triglycerides (LCT) and had a total Developmental Toxicity Study in Rats and Rabbits Adminis- caloric value of approximately 2 kcal/mL . tered an Emulsion Containing Medium Chain Triglycerides as an MCT (6 to 12 carbon fatty acids), unlike LCT (greater Alternative Caloric Source. Henwood, S., Wilson, D., White, R., and Trimbo, S. (1997). Fundam. AppL Toxicol. 40, 185-190. than 12-carbon fatty acids), are not stored as fat within the body ; they are rapidly and completely oxidized (Johnson Triglyceride-containing lipid emulsions have been designed as and Cotter, 1985). When administered in combination with caloric sources that can be administered intravenously t