原创力文档Expression of MIP-1α (CCL3) by a Recombinant Rabies Virus Enhances Its Immunogenicity by Inducin.pdf
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Expression of MIP-1α (CCL3) by a Recombinant Rabies Virus Enhances Its Immunogenicity by Inducin
JOURNAL OF VIROLOGY, Sept. 2010, p. 9642–9648 Vol. 84, No. 18
0022-538X/10/$12.00 doi:10.1128/JVI.00326-10
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Expression of MIP-1 (CCL3) by a Recombinant Rabies Virus
Enhances Its Immunogenicity by Inducing Innate Immunity
and Recruiting Dendritic Cells and B Cells
1 1 1,2 1 1
Ling Zhao, § Harufusa Toriumi, †§ Hualei Wang, § Yi Kuang, Xiaofeng Guo, ‡
Kinjiro Morimoto,3 and Zhen F. Fu1,4*
Departments of Pathology 1 and Infectious Diseases,4 University of Georgia, Athens, GA 30602; College of
Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China 2; and
Yasuda Women’s University, Hiroshima 731-0153, Japan3
Received 11 February 2010/Accepted 24 June 2010
Previously, we showed that overexpression of MIP-1 in mouse brain further decreased rabies virus (RABV)
pathogenicity (L. Zhao, H. Toriumi, Y. Kuang, H. Chen, and Z. F. Fu, J. Virol., 83:11808–11818, 2009). In the
present study, the immunogenicity of recombinant RABV expressing MIP-1 (rHEP-MIP1) was determined.
It was found that intramuscular immunization of BALB/c mice with rHEP-MIP1 resulted in a higher level of
expression of MIP-1 at the site of inoculation, increased recruitment of dendritic cells (DCs) and mature B
cells into the draining lymph nodes and the peripheral blood, and higher virus-neutralizing antibody titers
than immunization with the parent rH
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