右旋糖苷_阿司匹林高分子挂接药物的体外释放.pdfVIP

　第28 卷第3 期 合肥工业大学学 报( 自然 科 学 版 ) Vol. 28 No. 3　 　2005 年3 月 JOURNAL OF HEFEI UNIVERSIT Y OF TECHNOLOGY M ar. 2005　 - 高文霞, 　姚日生, 　张霄翔 ( , , 230009) : - , (ASA) , ASA , , , , , , ; , ASA : -; ; : R969. 1; T Q 63. : A : 1003-5060( 2005) 03-0282-0 Study of in vitro release of dextran-aspirin conj ugate GAO Wen-xia, YAO Ri-sheng, ZHANG Xiao-xiang ( School of Chemical Engineering, Hefei University of T echnology, Hefei 230009, China) Abstract: The objective of this study is to evaluate in v it ro release behavior of dextran-aspirin - . conjugates with different drug loading ratios in artificial gastric juice and artificial intestinal juice Wavelengths of aspirin in different media were detected first. Then the standard line of concentration to absorption w as made to get the regression equation. The in v itro release study was carried out then in different release media under determinate temperature and rotating speed The conjugates had a. linear release of aspirin v s time w ith no abrupt release And the release rate w as nearly zero order. . The release rate in artificial gastric juice w as low er than that in artificial intestinal juice. The release rate enhanced w ith the increase of the drug-loading ratio . T he dextran-aspirin conjugate is stable in , - the acid environment of the stomach w hich may lead to less side effect and stimulation of aspirin on the gastrointestinal ( GI) tract. Whats more, the dextran-aspirin conjugate has a sustained release of aspirin. Key words : dextran-aspirin conjugate; in v i tro release; sustained release 20 70 , [ 1] , , , , ,