茶叶血小板活化.pdfVIP

茶叶科学 2015，35 （5 ）：458~464 Journal of Tea Science 投稿平台： 茶叶对血小板活化的影响研究进展 陈萍，邱培，程浩，周盈，龚淑英* 浙江大学茶学系，浙江 杭州 310058 摘要：血小板活化是许多心血管疾病的发病基础，抗血小板药物能够在不同水平阻断血小板聚集作用的级联 反应。临床医学和动物实验证实，茶叶及有效成分对血小板活化具有抑制作用，在抗血栓活性上表现出一定 的构效关系。本文从饮茶及茶叶成分对血小板聚集、血栓、凝血系统等方面的体内外研究进展进行综述，探 讨茶叶抑制血小板活化的不同作用机理，有助于系统阐明茶叶抗血栓、预防心血管疾病功能。 关键词：茶叶成分；血小板活化；血小板聚集；抗血栓 中图分类号：TS272 ；Q461 文献标识码：A 文章编号：1000-369X（2015 ）05-458-07 Review on the Effect of Tea on Platelet Activation * CHEN Ping, QIU Pei, CHENG Hao, ZHOU Ying, GONG Shuying Department of Tea Science, Zhejiang University, Han gzhou 310058, China Abstract: Platelet activation is the basis of the incidence of many cardiovascular disease, antiplatelet drugs could block the cascade of platelet aggregation in different levels. As confirmed by clinical research and animal experiments, tea and tea ingredients can inhibit platelet aggregation . Catechins exhibit a structure-activity relationship in antiplatelet effect . This review summarized recent progress in the effect of tea and tea ingredients on platelet activity or platelet aggregation in vitro, in vivo and ex vivo, and also the effect on thrombus and coagulation system. The mechanism of anti-aggregatory effect of tea is explored, which provide further confirmation for its antithrombotic function and the preventive effect for cardiovascular disease . Keywords: tea ingredients, platelet activation, platelet aggregation, antithrombotic 血小板 （Blood platelet ）是血液中最小的 1 血小板活化与抗血小板药物 血细胞，是机体实现正常止血功能的主要成 分，对凝血系统的激活也至关重要。而血小板 血小板活化包括血小板粘附、聚集和释放 过度活化则是许多心血管疾病