超声聚焦刀联合化疗治疗宫颈癌同步放化疗后宫颈肿瘤残留临床观察.doc

超声聚焦刀联合化疗治疗宫颈癌同步放化疗后宫颈肿瘤残留的临床观察 　　【摘要】 目的：探讨超声聚焦刀联合化疗治疗宫颈癌同步放化疗后肿瘤残留的近期疗效和安全性。方法：收集本科2013年1月-2016年3月收治的ⅡB～ⅣA期宫颈癌经同期放化疗后宫颈肿瘤残留患者97例，随机法分为试验组47例和对照组50例。试验组采用TP方案（紫杉醇+顺铂）+超声聚焦刀，对照组仅采用TP方案（紫杉醇+顺铂），两组均给予化疗2个周期，比较两组的治疗效果及毒副反应。结果：两组患者均完成全部治疗及随访，试验组有效率为95.7%，对照组为82.0%，两组比较差异有统计学意义（P0.05）。结论：超声聚焦刀联合化疗治疗宫颈癌同步放化疗后宫颈肿瘤残留，能提高患者的近期疗效，不增加全身毒副反应，安全性好，是值得临床进一步研究推广的安全有效方法 【关键词】 超声聚焦刀； 宫颈癌； 肿瘤残留； 辅助化疗； 紫杉醇顺铂 Clinical Observation of HIFU Combined with Chemotherapy in the Treatment of Cervical Cancer with Concurrent Chemoradiotherapy Cervical Residual Tumor/ZHANG Hong-li，CHEN Yan-ping，WU Li，et al.//Medical Innovation of China，2016，13（22）：011-015 【Abstract】 Objective：To investigate the short-term efficacy and safety of HIFU combined with chemotherapy in the treatment of cervical cancer with concurrent chemoradiotherapy cervical residual tumor.Method： 97 patients with cervical cancer were collected from January 2013 to March 2016 in our department of ⅡB-ⅣA who were treated with concurrent radiotherapy and chemotherapy，they were randomly divided into experimental group of 47 cases and control group of 50 cases.The experimental group was given TP （paclitaxel + cisplatin）+HIFU，control group was given TP （paclitaxel + cisplatin）.The effective rate and side effects of two groups were compared.Result：Two groups were completed all treatment and follow-up，the effective rate of experimental group was 95.7%，control group was 82.0%， the difference was statistically significant （P0.05）.Conclusion：HIFU combined with chemotherapy in the treatment of cervical cancer concurrent chemoradiotherapy cervical residual tumor，can improve the patients curative effect in the near future， does not increase the systemic toxic and side effects，has good safety，it is worthy of further clinical research and promotion of safe and effective method. 【Key words】 High intensity focused ultrasound； Cervical cancer； Residual tumor； Adjuvant chemotherapy； Paclitaxel cisplatin First-authors address：The Peoples Hos