电位滴定法测定盐酸安他唑啉含量.docVIP

电位滴定法测定盐酸安他唑啉含量 　　[摘要]目的 建立快速、准确、环保、灵敏度高的测定盐酸安他唑啉含量的方法。方法 采用Mettler DL-50自动电位滴定仪，以5.0 ml盐酸和50 ml乙醇作溶剂，氢氧化钠做滴定剂进行电位滴定，比较电位滴定法与非水滴定法的结果。结果 取样量在0.12～0.35 g范围内，线性良好，r=0.9998（n=6），准确度RSD为0.3%，重复性RSD为0.2%和0.3%。电位滴定法与非水滴定法测定结果一致。结论 电位滴定法快速、准确、灵敏，且消除了现行方法对环境的污染因素，可作为盐酸安他唑啉含量的测定方法 [关键词]盐酸安他唑啉；电位滴定法；含量测定 [中图分类号] R927.2 [文献标识码] A [文章编号] 1674-4721（2016）09（a）-0009-03 Determination of sntazoline hydrochloride potentiometric titration ZHANG Wen-jie Departmentof Parmacy，the Second Hospital Affiliated to Shenyang Medical College，Shenyang 110002，China [Abstract]Objective To establish a rapid and accurate，environmental protection，high sensitivity method for the determination of antazoline hydrochloride.Methods The potentiometric titration was performed on Mettler DL-50 and Mettler DG115-GC using 5.0 ml hydrochloric acid and 50 ml ethylalcohol as solvent and Sodium hydroxide as titrantion.The potentiometric titration in contrast was compared with non-aqueous titration method.Results The linear range of weight was 0.12 to 0.35g（r=0.9998，n=6），the RSD of accuracy experiment and repeatability experiment were 0.3%，0.2% and 0.3%.Potentiometric titration and non-aqueous titration results were consistent.Conclusion Potentiometric titration method is fast，accurate，sensitive，and elimination of the existing methods of environmental pollution factors，can be used as bupropion hydrochloride his method for the determination of imidazoline [Key words]Antazoline hydrochloride；Potentiometric titration；Determination 盐酸安他唑啉是一种4，5-二氢-N-苯甲基-1H-咪唑-2-甲胺盐酸盐，是抗组胺受体拮抗剂，具有抗组胺和抗胆碱作用。通过干扰心肌细胞膜对钠、钾离子的渗透，减慢心肌的传导，轻度阻滞交感神经，来增加周围血管的阻力及降低心排血量。临床上主用于治疗房性、室性早搏，室性心动过速，房颤等心律失常及过敏性疾病[1-3]。查找相关资料，并未发现相关的药品不良反应报告。临床常应用其制成100 mg的薄膜衣片和注射剂。《中国药典》2015版[4]中盐酸安他唑啉项下规定盐酸安他唑啉的含量为不低于98%，测定方法为非水滴定法。非水滴定法测定滴定剂为高氯酸，滴定过程中需加醋酸汞试液，消除本品中盐酸盐对滴定结果的影响。醋酸汞具有较大毒性，能造成环境污染，同时对操作人员的劳动保护要求较高。为寻找一种方便可行、减少污染、降低企业操作成本的方法，本文参照《英国药典》[5]采用电位滴定的方法对盐酸安他唑啉的含量测定方法进行了研究。该方法供试品溶液溶解快速，滴定剂及指示剂配制简单方便，有两个明显的滴定突跃，便于结果观察，符合电位滴定要求，且该方法操作简便、试验灵敏度高、对