α-Alkylation and Catalytic Alkylation.ppt

2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.6 CHIRAL CATALYST-INDUCED ALDEHYDE ALKYLATION: ASYMMETRIC NUCLEOPHILIC ADDITION 2.2.3.3 Imide Systems Wenglowsky and Hegedus32 reported a more practical route to a-amino aldehydes via an oxazolidinone method. As shown in Scheme 2-20, chiral diphenyl oxazolidinone 26 is first converted to allylic oxazolidinone 27; subsequent ozonolysis and imine formation lead to compound 28, which is ready for the a-alkylation using the oxazolidinone method. The results are shown inTable 2-6. 2.2.3.3 Imide Systems 2.2.3.4 Chiral Enamine Systems 2.2.3.4 Chiral Enamine Systems 2.2.3.5 Chiral Hydrazone Systems In 1976, Corey and Enders34 demonstrated the great synthetic potential of metalated dimethylhydrazones as highly reactive intermediates in regio- and diastereoselective C-C bond formation reactions. The procedure for carrying out the electrophilic substitution reaction at the a-carbon of the carbonyl group is shown in Figure 2-2. 2.2.3.5 Chiral Hydrazone Systems 2.2.3.5 Chiral Hydrazone Systems 2.2.3.5 Chiral Hydrazone Systems 2.2.3.5 Chiral Hydrazone Systems 2.2.3.6 Oxazoline Systems 2.2.3.6 Oxazoline Systems 2.2.3.6 Oxazoline Systems 2.2.3.6 Oxazoline Systems 2.2.3.6 Oxazoline Systems 2.2.3.7 Acylsultam Systems 2.2.3.7 Acylsultam Systems 2.2.3.7