神经营养因子.pptx

神经营养因子;提纲; 研究历史及研究启示; 研究历史及研究启示; 研究历史及研究启示;Purves et al., 2001; 研究历史及研究启示;研究历史及研究启示; 研究历史及研究启示; 研究历史及研究启示; 研究历史及研究启示;; 研究历史及研究启示;提纲;神经营养因子的概念;神经营养因子的概念;神经营养因子在机体中的分布;提纲;神经营养因子的分类;;;;neurotrophin, NTs家族;Neurotrophins in the CNS;neurotrophin受体分类;;trkA 结构;内化作用;;;Differential control of TrkA trafficking and signaling may also be the basis for the different functions of NGF and NT-3;跨膜转导;;;;;;;;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;14-3-3;Trk receptor signaling;;;p75NTR 结构;57;Nerve growth factor (NGF) signaling;NGF was found to exist in both unprocessed (pro) and mature forms. The mature NGF preferentially activates TrkA, whereas proNGF only activates p75NTR. Importantly, proNGF is much more efficient than NGF at inducing the death of responsive cells;The p75 can bind to each neurotrophin, and also acts as a co-receptor for Trk receptors. Expression of p75 can increase the affinity of TrkA for NGF and can enhance its specificity for cognate neurotrophins. Increased ligand selectivity can be conferred on the Trk receptors by the p75 receptor. ;p75NTR is required for developmental myelination;只有在trk不激活或处于非最佳激活状态时P75NTR才 会诱导凋亡；;提纲;NTFs的作用方式;逆行信号转导 ;target organ;顺行信号转导;;NTFs的局部作用;神经鞘合成NTFs;胶质细胞介导的间接神经营养作用 ;;;神经元合成NTFs;自分泌作用;自分泌作用;非分泌方式的NTFs;提纲; 发育期;促进神经元活存、生长;促进神经元活存、生长;;Sympathetic neurons were placed in a TC system that allowed the somas and neurites to be bathed in different media. L: Most neurons die when grown without NGF for 30 hr. R: Neurons can be kept alive by adding NGF only to the compartments with growing neurites.;发育期;三、NTs生物学效应 (一) 发育期;; 发育期;;;发育期;;Nerve Growth Factor Supports Survival and Differentiation of Neurons;;成年期;;损伤修复期;损伤修复期;;;损伤修复期;神经生长因子在神经系统外的作用;谢谢聆听！