糖尿病心肌病相关信号通路的研究进展.pdfVIP

第26卷第10期 生命科学 Vol. 26, No. 10 2014年10月 Chinese Bulletin of Life Sciences Oct., 2014 DOI: 10.13376/j.cbls/2014155 文章编号：1004-0374(2014)10-1084-06 糖尿病心肌病相关信号通路的研究进展 1,2 1,3* 尹茂山 ，牟艳玲 (1 济南大学- 山东省医学科学院医学与生命科学学院，济南 250062 ；2 山东省医学科学院 药物研究所，济南 250062 ；3 山东省罕少见病重点实验室，济南 250062) 摘　要 ：糖尿病心肌病是一种独立、特异的心肌病，与糖尿病患者发生心力衰竭和死亡率升高密切相关。 高血糖引起的心血管并发症涉及心肌病变和血管病变、心肌细胞结构的改变、信号通路和炎症因子的改变等， 导致心肌纤维化、心肌肥厚、心脏肥大、心力衰竭和心律失常。综述了糖尿病心肌病发病机制中研究较多 的几条信号通路，探究各信号通路在糖尿病心肌病发生、发展过程中对心脏的保护( 损伤) 作用的相关研 究进展。 关键词：糖尿病心肌病；信号通路；发病机制 R587.1 R542.2 中图分类号： ； 　　 文献标志码：A Research progress of diabetic cardiomyopathy-associated signaling pathways YIN Mao-Shan1,2, MU Yan-Ling1,3* (1 School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, China; 2 Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China; 3 Key Laboratory for Rare Disease of Shandong Province, Jinan 250062, China) Abstract: Diabetic cardiomyopathy is an independent, specific cardiomyopathy, closely related with heart failure and high mortality. Cardiovascular complications related to hyperglycemia induced cardiomyopathy and pathophysiology of vascular disease, changes of myocardial structure, the signaling pathways, and alteration in inflammatory cytokines, leading to myocardial fibrosis, myocardial hypertrophy, cardiac hypertrophy, heart failure and arrhythmias. The paper mainly reviewed several signaling pathways which studied more on the pathogenesis of diabetic cardiomyopathy, to explore the various signaling