烷基酚类物质的生殖发育毒效应及其作用机制_卞倩.pdf

33 　3 　　　 Vol.33　No.3 2004 　5 JOURNAL OF HYGIENE RESEARCH May 　2004　357 :1000-8020 (2004)03-0357-04 ·· 卞倩 综述　王心如 审校 , 　210029 :烷基酚类化合物(alkylphenol compounds, APs)因其长期的广泛应用与在环境中的大 滞留, 已成为 最常见的环境污染物之一, 与之相关的环境内分泌干扰效应已越来越成为关注的热点和亟待研究与解决的 问题。 本文拟对APs 及其相关化合物的生殖内分泌干扰效应和作用机制做初步论述。 :烷基酚类化合物　生殖 发育毒性　内分泌干扰效应 :R994.6 　Q492 　　　　　　:A Toxic effect and mechanism of alkyl-phenol compounds on reproduction and development Bian Qian, Wang Xinru Institute of Applied Toxicolo y, Nanjin Medical University, Nanjin 　210029, China Abstract:Alkylphenol compounds (APs)is one of most common environmental pollutants due to wide use and abroad existence in environment.There has been increasin concern about its impact to the endocrine sy stem that need to be investi ated.In this paper, the toxic effect and mechanism of APs on reproduction and development was reviewed. Key words:alkylphenol compounds(APs), toxicity, reproduction, development, endocrine 　　APs (APEs ApnEO, n (OPEs) 15%, ), APEs 。 。APEs 。 APEs 20 APs APEs , 40 , 80 , CO H O, , 2 2 。 , APEs 。 , APs 。 、、、 1938 APs , 90 ;, APEs