单晶衍射实例-3.pdfVIP

ORGANIC LETTERS Conosilane A, an Unprecedented XXXX Vol. XX, No. XX Sesquiterpene from the Cultures of 000–000 Basidiomycete Conocybe siliginea Xiao-Yan Yang,†,‡ Tao Feng,† Zheng-Hui Li,† Yu Sheng,§ Xia Yin,†,‡ Ying Leng,§ and Ji-Kai Liu*,† State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China, Graduate School of Chinese Academy of Sciences, Beijing 100039, P. R. China, and Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China jkliu@ Received September 6, 2012 ABSTRACT Conosilane A (1), a novel sesquiterpene with an unprecedented carbon skeleton, was isolated from the cultures of the basidiomycete Conocybe siliginea. Its structure was elucidated by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Conosilane A was found to inhibit 11β-hydroxysteroid dehydrogenase significantly. The genus Conocybe belongs to the order Agaricales and mushroom C. siliginea has been proven to be a rich resource family Bolbitiaceae, which comprises more than 240 spe- of sesquiterpenes, from which we have reported a series of cies all over the world. Previous investigations of the genus