左旋多巴联合综合疗法治疗青少年屈光不正性弱视效果与对患者视功能与P―VEP影响.doc

左旋多巴联合综合疗法治疗青少年屈光不正性弱视的效果及对患者视功能和P―VEP的影响 　　[摘要]目的 探讨左旋多巴联合综合疗法治疗青少年屈光不正性弱视的效果及对患者视功能和P-VEP水平的影响。方法 将2012年8月～2015年3月于我院眼科确诊为屈光不正性弱视的84例青少年患者纳入研究并随机分组，对照组41例采用综合疗法，治疗组43例则联合左旋多巴，6个月为1个疗程。比较两组治疗前后视觉敏感度、P-VEP和视功能、临床疗效及不良反应差异。结果 治疗后，患者P-VEP P100波幅升高及不同空间频率下的对比度均升高，P-VEP P100波潜伏期则缩短，但治疗组改善更显著（P0.05）。结论 左旋多巴联合综合疗法治疗青少年屈光不正性弱视的效果显著，值得推广 [关键词]左旋多巴；综合疗法；青少年；屈光不正性弱视；视功能；P-VEP值 [中图分类号] R778.1 [文献标识码] A [文章编号] 1674-4721（2016）10（a）-0123-04 [Abstract]Objective To explore the effects of Levodopa combined with comprehensive therapy in treatment of youth with ametropia amblyopia and the effects on patients′ visual function and P-VEP level.Methods 84 cases youth which were diagnosed as ametropia amblyopia in Department of Ophthalmology of our hospital from August 2012 to March 2015 were selected and randomly divided into two groups.41 patients in control group were treated with combined therapy，while 43 patients in treatment group were treated with Levodopa combined comprehensive therapy，6 months as a course of treatment.After 6 months，the visual acuity，P-VEP，visual function before treatment and after treatment，clinical effects and adverse reactions between two groups were compared.Results After treatment，the patients′ P-VEP P100 amplitude and the contrast in different spatial frequency increased，while P-VEP P100 wave latency shortened，the improvement of the treatment group was more significant （P0.05）.Conclusion There is significant effect of Levodopa combined with comprehensive therapy on ametropia amblyopia of the youth.The method can improves more visual function and is worth popularizing. [Key words]Levodopa；Comprehensive therapy；Youth；Ametropia amblyopia；Visual function；P-VEP level 屈光不正性弱视是弱视的一大类型，约占弱视发病率的30.76%，一直是眼科研究的重点及热点[1]。儿童时期积极采用综合疗法治疗可使大多患者取得显著效果，使视力恢复正常[2]。但是对于病情较重者综合疗法效果则往往不理想，加之部分患者依从性差，或失治误治，导致青少年患者的治疗难度往往更大[3]。研究表明，左旋多巴可延长视觉发育敏感期，有助于患者视力恢复。现报道在常规治疗的基础上联合左旋多巴治疗的效果如下。 　　1资料与方法 1.1一般资料 将2012年8月～2015年3月于我院眼科确诊为屈光不正性弱视的84例青少年患者纳入研究并随机分组，其中对照组41例，总