肝豆状核变性患者胆囊收缩功能与血浆CCK`VIP水平关系的研究.doc

肝豆状核变性患者胆囊收缩功能与血浆CCK、VIP水平关系 徐磊,蔡永亮,陈怀珍,徐国存,李俊,葛青,张静 安徽中医学院第一附属医院神经内科 合肥市 230031 通讯作者:蔡永亮，230031，安徽省合肥市梅山路117号，安徽中医学院第一附属医院神经内科，CYL9797@.sina 电话：0551-2838706 Relationship Study of The Gallbladder Contraction Rate And The Contents of Plasma CCK,VIP of HLD Patients. Xu Lei,Cai Yong-liang,Chen Huai-zhen,Xu Guo-cu,Li Jun,Ge qing,Zhang Jing. Deparment of Neurology of First Affiliated Hospital of Anhui College of Traditinal Chinese Medicine,Hefei, 230031, China Corresponding author:Cai Yong-liang, Deparment of Neurology of First Affiliated Hospital of Anhui College of Traditinal Chinese Medicine,117# Meishan Road,Hefei,230031,China. CYL9797@ Abstract AIM:To investigate the correlation between the Contractile Function of Gallbladder and the contents of plasma cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) in Hepatolenticular degeneration(HLD) patients. METHODS: The contents of plasma CCK and VIP in 37 HLD patients were deter- mined by radioimmunoassay(RIA),and compared with those in the healthy persons. The surface areas of gall bladder of HLD patients measured by B-Ultrasound before and after Fat Diets. RESULTS: The contents of plasma CCK and VIP in HLD patients were significantly higher than those in healthy control (P﹤0.05). The surface areas of gall bladder of HLD patients before Fat Diets were significantly larger than those in healthy control (P﹤0.05).No significant change in The surface areas ofgallbladder before Fat Diets between HLD group and control group (P﹥0.05),the gallbladder contraction rate in HLD group were significantly less than those in control group (P﹤0.05). CONCLUSION: The high contents of plasma CCK and VIP plays an important role in the Contractile Function of Gallbladder of HLD patients. Key Words: HLD； contractile function of gallbladder； CCK； VIP 摘要目的探讨HLD患者血浆胆囊收缩素（CCK）、血管活性肠肽（VIP）水平与胆囊收缩功能的关系。方法选择符合诊断标准的HLD患者37例， 37位健康人为对照组。采用放射免疫法检测两组血浆CCK、VIP水平，B超测定两组脂餐前后胆囊面积，计算胆囊收缩率。结果HLD组血浆CCK、VIP水平显著高于对照组（P﹤0.05）； HLD组脂餐前胆囊面积（BS）显