骨粒羟基磷灰石加粘合剂植入后骨生长过程的实验研究_百替生物.pdfVIP

骨粒羟基磷灰石加粘合剂植入后骨生长过程的实验研究 中国临床解剖学杂志 2000年第3期第18卷 实验研究 作者：施长友 崔功浩 单位：施长友(310004 杭州市 杭州卫生学校解剖学教研室)；崔功浩(浙江大学医学院 解剖学教研室) 关键词：骨粒；羟基磷灰石；粘合剂 【摘 要】 目的：研究以骨粒羟基磷灰石为粉碎性骨折及骨肿瘤切除术后作为骨质 缺损的填充和固定应用，提供科学依据。方法：将骨粒羟基磷灰石加粘合剂，填入钻孔后 的兔胫骨孔内，每月一次，分四批处死兔子，取出填入处胫骨作组织学切片，观察新生骨 形成过程。结果：发现单纯羟基磷灰石填入处的羟基磷灰石周围，形成紧密包裹的骨膜样 组织，新生骨细胞不能长入到羟基磷灰石内；而加入骨粒后的羟基磷灰石的材料，能见到 新生骨组织长入到羟基磷灰石内，形成网状结构与受体骨组织牢固紧密结合。结论：骨粒 羟基磷灰石加粘合剂作为填充材料，能使骨粒吸收，新生骨组织通过被破坏、吸收的骨粒 的通道长入新生骨，从而使受体骨组织和羟基磷灰石紧密牢固地结合在一起。 ExperimentalstudiesonthebonedevelopmentaftertheimplantationofHAcombined with bone granules Shi Changyou,Cui Gonghao. Department of Anatomy,Hangzhou Health School,Hangzhou 310004 Objective:To provide the scientific basis for the filling and repairing of the postoperative bone defect and comminuted fracture.Methods:Hydroxyapatite(HA)combined with bone granules and cement was implanted into the holes of rabbit tibias.The implanted parts of the tibias were observed with tissue slice technique at four monthly stages.Results:Periosteal tissues were formed around the HA implanted area which prevented the filtration of the osteoblast cell.When the bone granule and HA were implanted together,new bone tissue could be found in the HA,forming a network structure and combining tightlywiththerecipient’sbonetissues.Conclusion:Whenthebonegranuleswere implanted into the hole of bone with HA together,they can be absorbed and from tunnels.The new bone tissue can develop along the tunnels and form a network,therefore combine with the implanted HA tightly. Key words Bone granules HA Cement 本课题研究的人工骨材料为骨科粉碎性骨折及骨肿瘤切除后造成的骨质缺损时作为 填充和固定应用。近几十年来国内外常用骨水泥作为骨质缺损后的填充材料。但许多文献 报道表明，临床上应用的各种骨水泥，均不能保持长期的固定，后期骨面处松动、破裂率