前列地尔联合甲钴胺治疗糖尿病神经病变的临床疗效及其对 .docVIP

前列地尔联合甲钴胺治疗糖尿病神经病变的临床疗效及神经传导速度的影响 周丽华 （海南省农垦总医院内分泌科，海南 海口 570311） 【摘要】目的：探究与分析前列地尓联合甲钴胺对糖尿病神经病变患者的临床治疗效果和神经传导速度的影响。方法：特选取自2012年12月起至2015年1月在我院接受治疗的糖尿病神经病变患者118例，并按照数字表法随机分为试验组与对照组两组，每组均59例。两组患者均给予运动及常规饮食治疗，在此基础上，予以对照组前列地尓进行治疗，试验组患者则采用前列地尓联合甲钴胺的治疗方案。对比两组患者的临床治疗效果及治疗前后的神经传导速度。结果：试验组临床总有效率（93.22%）与对照组的（67.80%）相比明显较高，统计学上有意义（P0.05）；治疗前，两组的正中神经、腓神经、正中运动神经及腓运动神经差异比较，统计学上无意义（P0.05）；经过治疗后，试验组患者的正中神经（51.11±3.62）m/s、腓神经（49.99±3.52）m/s、正中运动神经（67.70±3.31）m/s及腓运动神经（49.98±3.40）m/s均明显优于对照组患者的正中神经（41.17±3.21）m/s、腓神经（43.46±3.29）m/s、正中运动神经（56.08±3.22）m/s及腓运动神经（43.41±3.07）m/s，统计学上有意义（P0.05）。结论：给予糖尿病神经病变患者前列地尓联合甲钴胺进行治疗后，其整体神经病变症状显著好转，神经传导速度也明显增加，作用效果显著。 【关键词】前列地尓；神经传导速度；甲钴胺；糖尿病神经病变 Clinical efficacy of alprostadil combined with mecobalamin in the treatment of the patients with diabetic neuropathy and its impact on nerve conduction velocity ZHOU Li-hua (Department of Endocrinology, Hainan Reclamation General Hospital, Hainan Haikou 570311) Abstract Objective: To explore and analyze clinical effect of alprostadil combined with mecobalamin in the treatment of the patients and impact on nerve conduction velocity. Methods: from December 2012 until January 2015, 118 cases of diabetic neuropathy patients in our hospital, and in accordance with throwing a coin were divided into the experimental group and the control group, 59 cases of patients in each group. Two groups of patients were treated with exercise and diet routine treatment, and the control group were treated with alprostadil treatment, the experimental group are given alprostadil combiend with mecobalamin treatment. Before and after treatment clinical results and nerve conduction velocity of two groups of patients are compared. Results: The clinical overall response rate of the experimental group (93.22%) was significantly higher than the control group (67.80%), with statistically significant difference (P 0.05); Before treatment, two groups of patients with median nerve, peroneal nerve, median motor nerve and peroneal motor nerves