分子生物肿瘤molecular+biology+of+cancer2h.ppt

The pattern of retrovirus particle Transformed retrovirus Carrying a cope of cellular sequence replaced a part of self gene. Papilloma Viruses 10% human tumor related to HPV. DNA tumor virus Adenoviruses E1A and E1B = Oncogenes E1A can bind with RB protein and cause cells hyperplasia or cancer. Human herpes virus 8 (Kaposi sarcoma-associated virus) Herpes Viruses Herpes simplex 2 (cervical carcinoma?) Herpes 疱疹 hepatocellular carcinoma Hepatitis B virus Viral oncogenes may cause cells to become cancerous through three ways: Homologous recombination of V-onc and proto-onc can cause proto-onc activation and become oncogene. The products of V-onc can interfere the normal growth of cells, especially inhibit the control function of cell growth. V-onc and C-onc can co-express high level of oncoptrotein which can cause cells to become cancerous. The products of V-onc can interfere the signal transduction for normal cell growth. The products of V-onc can inhibit the function of P53 protein. Hereditary V-onc Cellular oncogene For instance: erbB gene C-oncs are over-activated or over-expressed proto-oncogenes. Proto-oncogenes are kinds of normal cellular genes. They code key control proteins in normal cells and play very important role in cell proliferation and differentiation. The proto-oncogenes can cause cells to become cancerous only when they are mutated. Proto-oncogene Activation of cellular oncogene Classification of cellular oncogenes: Some cellular oncogenes and their products: Tumor suppressor gene Tumor suppressor genes are also normal genes in normal cell and can negatively regulate cell proliferation. The cells will become cancerous when tumor suppressor genes lost or inactivated. Tumor suppressor genes play their control function in the cell cycle. G1, S, G2 and M phase are all check points in the cell cycle. Tumor suppressor genes can negatively regulate normal cell growth by inhibiting cell proliferation and inducing cell differentiation. Cell cyc