脂肪组织来源间充质干细胞生物学特性和和肥胖的关系.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(2): 236–24 1 DOI: 10.11844/cj cb.2014.02.0317 脂肪组织来源间充质干细胞生物学特性及与肥胖的关系 * * 吕 涛 肖 苒 曹谊林 ( 中国医学科学院整形外科医院研究中心, 北京100144) 摘要 脂肪组织来源间充质干细胞(adipose tissue-derived stem cells, ADSCs) 因储量丰富、获 取简便、扩增迅速、可被诱导多向分化、免疫原性低等诸多优点受到广泛关注, 为多种疾病的治 疗提供了新思路。肥胖及其相关疾病的发生率日益上升, 严重影响人类的生存质量。ADSCs在肥 胖的发生和发展过程中起着不可忽视的作用。该文着重对近十年ADSCs的生物学特性研究进展及 其在肥胖发生与发展中的作用进行综述, 为其早日应用于临床实践提供参考。 关键词 脂肪组织来源间充质干细胞(ADSCs); 血管周膜细胞; 免疫表型; 肥胖因子; 肥胖 Adipose Tissue-derived Stem Cells Biological Properties and It’s Role in Obesity Lü Tao, Xiao Ran*, Cao Yilin* (Plastic Surgery Hospital, Peking Union Medical College, Beijing 100144, China) Abstract Adipose tissue-derived stem cells (ADSCs) provide a promising future for the therapy of mul- tiple diseases due to their abundance, easy of availability, low immunogenicity, huge potential of proliferation and multilineage differentiation abilities. The relationship between ADSCs and obesity is becoming the focus of the public due to the epidemic of obesity and ADSCs connection with it. The current review focuses on the latest research progresses about ADSCs biological characteristics and their correlation with obesity, aiming at provid- ing a theoretical reference for their future application in clinical practice. Key words adipose tissue-derived stem cells; mural cells; immunophenotype; obesogen; obesity 引言 1 ADSCs的生物学特性 脂肪组织来源的间充质干细胞(adipose ti- 2005年, 国际细胞治疗组织(the International So- ssue-derived stem cells, ADSCs)是一类易于获得、 ciety for Cellular Therapy)规定间充质干细胞(MSCs) [1] 增殖和分