布拉氏酵母菌作为抗Hp根除疗法的辅助用药,对Hp根除率及相关性不良反应的评估.pdfVIP

Alimentary Pharmacology Therapeutics Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy J. L. TONG*, Z. H. RAN*, J. SHEN*, C. X. ZHANG S. D. XIAO* *Department of Gastroenterology, SUMMARY Shanghai Institute of Digestive Dis- ease, Renji Hospital, Shanghai Jiao Background Tong University, School of Medicine, Recent evidence found probiotics could inhibit Helicobacter pylori col- Shanghai, China; Department of onization from both in vitro and in vivo studies. Pharmacy, Jiangni Hospital, Nanjing, China Aim Correspondence to: To systematically evaluate whether adding probiotics to anti-H. pylori Dr Z. H. Ran, Department of regimens could improve eradication rates and reduce side effects during Gastroenterology, Shanghai Institute of Digestive Disease, Renji Hospital, anti-H. pylori treatment. Shanghai Jiao Tong University, Methods School of Medicine, Shanghai 200001, China. Eligible articles were identified by searches of electronic databases. We E-mail: z-ran@ included all randomized trials comparing probiotics supplementation to placebo or no treatment during anti-H. pylori regimens. Statistical ana- Publication data lysis was performed with Review Manager 4.2.8. Subanalysis/Sensitivity Submitted 23 August 2006 analysis was also performed. First decision 13 September 2006 Resubmitted 26 September 2006 Results Resubmitted 07 October 2006 We identified 14 randomized trials (n ¼ 1671). P