脂肪炎症细胞因子在I型糖尿病中的作用—脂肪组织和I型糖尿病.pdfVIP

QianRen Biology 千人·生物, 2016, 3(1), 1-6 Published Online February 2016 in Hans. /journal/qrb /10.12677/qrb.2016.31001 The Role of Adipose-Derived Inflammatory Cytokines in Type 1 Diabetes —Adipose Tissue and T1D Lan Shao, Boya Feng, Yuying Zhang, Huanjiao Zhou, Weidong Ji, Min Wang* The Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou Guangdong rd th th Received: Feb. 23 , 2016; accepted: Mar. 8 , 2016; published: Mar. 15 , 2016 Copyright © 2016 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract Adipocyte dysfunction correlates with the development of diabetes. Recent studies suggest that adipose tissue is not simply the organ that stores fat and regulates lipid metabolism, but also is the largest endocrine organ with immune functions. Mice with an adipocyte-specific deletion of a SUMO- specific protease SENP1 develop symptoms of type-1 diabetes mellitus (T1DM) resulted from beta cell damage. Cytokine profiling indicates that peri-pancreatic adipocytes (PATs) of SENP1-dificient mice have increased proinflammatory cytokine production compared with other adipose depots. Proinflammatory cytokines originated from PATs have direct cytotoxic effects on pancreatic islets, and also increase infiltration of immune cells by augmenting CCL5 expression in adjacent pan- creatic islets. Molecular analyses support that SUMOylation of NF-κB essential molecule (NEMO) in PATs leads to increased NF-κB activity, cytokine production and pancreatic inflammation. Thera- peutic attempting to ameliorate the T1DM phenotype should con