静脉注射sCD14对严重烫伤内毒素血症小鼠血清C-反应蛋白和降钙素原以及血糖水平的影响.pdfVIP

.531. Vol.30 No.6 实验与检验医学 第 30 卷第 6 期 EXPERIMENTAL AND LABORATORY MEDICINE Dec.2012 2012 年 12 月 ·论著· 静脉注射sCD14 对严重烫伤内毒素血症小鼠血清 C- 反 应蛋白和降钙素原以及血糖水平的影晌 万玲，胡晓路，张萍，王泊，王占科 (解放军第九四医院检验科，南京军区检验医学专科中心，江西南昌 33ω02) 摘要:目的观察可溶性白细胞分化抗原 14{:回luble Cluster of Differentiation , sCDI4)对严重烫伤内毒素血症模型小鼠血清 C-反应蛋白和降钙素原以及血糖的影响。方法 ω只健康昆明小鼠随机分为烫伤 sCD14 治疗组(n=20) ，烫伤治疗对照组(n= 20)和正常对照组(n=20) ，观察 3 组小鼠血清 C-反应蛋白和降钙素原以及血糖水平变化。结果烫伤 sCD14 治疗组小鼠血清 C-反应蛋白和降钙素原以及血糖水平均明显低于烫伤治疗对照组(PO.OI) ，但仍高于正常对照组(PO.OI)。结论静脉sCD14 治疗可降低严重烫伤内毒素血症机体炎症反应改善高血糖提示 sCD14 可作为改善严重创伤内毒素血症炎症反应和高血 糖的有效药物。 烫伤;内毒素 关键词:sCD14 ; C-反应蛋白;降钙素原;血糖 ô 申图分类号 R446.1 1 匀，R664， R-332 文献标识码 A 文章编号 1674-1129(2012)06-0531-02 I doi: 1O.3969/j.issn. 1674-1129.2012.06.∞3 Em饵ts of trea恤ent of sCD14 on 曲e serum CRPpCT and g1ucose of 回riously scalded mice W A N Lin, HU Xiaolu, ZHANG Ping, et 01. 白te 94th Hospito1 ofPLA , N(]J;也协飞g33∞02， China [A脑tract] Obj町创刊 To study the effects of treatment of sCD14 on the serum CRP,PCT and glucose of seriously scalded mice. Methods The healthy Kunming mice were divided randomly to the group of scald- ed mice wi也 sCD14 treatment (n=20), the group of scalded mice without sCD14 treatment (n=20) and the group of normal mice，由e levels of serum CRP,PCT and glucose of all groups were measured. Results 币le lev- els of serum CRP,PCT and glucose of the group of scalded mice with sCD 14 treatment were lower than 也at of 由e group of scalded mice without sCD14 treatment,but higher than that of the group of normal mice (P O.OI).Concl皿ion 哑le tre创ment wi出 sCD14 could contribute to amelìorate the inflam