Ca与信号09.ppt

Intracellular Ca2+ Signaling Guan sudong Department of Physiology Bengbu medical college Ca2+ gradient under resting condition Initiation of intracellular Ca2+ signal 2. Internal Ca2+ release from ER/SR 内质网/肌浆网 Ryanodine receptor (2) IP3 receptor (1) Ryanodine receptor (RyR): mediates the efflux of Ca2+ from the SR and plays a central role in excitation-contraction (E-C) coupling. 特点 1.所需钙阈值较低 1.5-2.0μM,咖啡因可降低此阈值,Mg可升高此阈值; 2.全或无的释放 为CICR正反馈介导 Mechanisms of E-C coupling 在骨骼肌和心肌，RyR是主要的细胞内钙释放通道。 Isoforms of RyR RyR1: S