Wnt信号通路与其在动物生长发育过程中的作用_韩琳.pdfVIP

2008, 16( 3): 47-52 Ch inese Journal of Veterinary Parasitolo y # # W nt信号通路及其在动物生长发育过程中的作用 1, 2 2 韩 琳 , 冯新港 ( 1. , 200234; 2. 200232) W nt途径是重要的细胞信号转导途径, 该途径参与了从胚胎到成体的 一系列控制胚胎早期的发育 定 细胞分化细胞增殖及生长的调控, 异常表达或激活该途径会导致各种疾病甚至肿瘤发生本文重点阐述了W nt 信号通路在胚胎发育细胞分化及其在肿瘤发生过程中的作用, 同时揭示深入研究W n t信号通路, 设计出阻断 W nt 通路的物质, 可为将来肿瘤的治疗开辟一条新的途径 : W n t信号通路; 胚胎发育; 细胞分化; 肿瘤发生 : Q81 : A : 1005-0868( 2008) 03-0047-06 WNT SIGNALING PATHWAY AND ITS ROLE DURING ANIMAL S GROWTH AND DEVELOPMENT 1 2 HAN L in , FENG X in- an ( 1. L if e and Env ironm ent Co llege of ShanghaiN orm al University, Shanghai 200234, China; 2. Shangha i Institute of Veter inary S cience, CAA S , Shanghai 200232, China Abstract W nt si nalin p lays an mi portant role in many processes of life, re ulatin early embryon ic develop- ment, cell differentiation, cell proliferation and row th. A bnorm al expression or activation ofW nt si nalin pathw ay w ill result in many d iseases and tumors. In the review w e focus on the roles ofW nt si nalin in embryon ic develop- ment, cell differentiation and tumori enesis. In add ition, it deserves further research on the components ofW nt si- nalin pathw ay to con trive valuab le tar ets for poten tial anticancer a ents. K e words: W nt si nalin pathw ay; embryon ic developm ent; cell d ifferentiation; tumori enesis W nt ( mouse mammary , W nt tumor virus, MMTV) , Nusse 1982 [ 1] , in-t 1 int-1