癫痫患者合并抑郁危险因素分析.PDF

癫痫患者合并抑郁的危险因素分析 有无基金项目（写明基金名称及基金编码） 作者姓名，作者单位（地址，邮政编码） 第一作者姓名及邮箱 【摘要 】目的：本研究的目的是探讨临床因素和癫痫患者的生活质量（quality of life， QOL）与癫痫患者合并抑郁的关系，寻找癫痫合并抑郁的危险因素。方法：2007 年 8 月至 2008 年 12 月在华山医院癫痫专病门诊就诊的 140 位癫痫患者参与了调查，患者完成汉密 尔顿抑郁量表-17 （Hamilton Depression Rating Scale-17，HAMD-17）和癫痫患者生活质 量量表-31 （Quality of Life in Epilepsy-31，QOLIE-31）的评定。应用多元逐步回归分 析各影响因素与癫痫患者合并抑郁的关系。结果：36 位癫痫患者存在抑郁（25.7％）。复 杂部分性发作（OR=0.112）和发作类型数量（OR=3.773）被认为是癫痫合并抑郁的临床危险 因素。对发作的担忧(OR 0.947)和社会功能 (OR 0.947)与癫痫患者合并抑郁的概率增加有 关。结论：在我国三级医院的癫痫专病门诊患者中，癫痫合并抑郁的患病率与其他国家的 报道相似。发作类型的数量、复杂部分性发作、对发作的担忧和社会功能与患者的抑郁情绪 相关。 【关键词 】 癫痫；抑郁症；危险因素；生活质量 Analysis of risk factors for depression in patients with epilepsy Authors Authors Department (city, Zip code) Corresponding author and Email 【Abstract】 Objective The purpose of this study was to investigate clinical aspects and quality of life (QOL) as risk factors for depression in patients with epilepsy. Methods One hundred and forty outpatients with a diagnosis of epilepsy who were attending our epilepsy center participated. Patients anonymously filled out a questionnaire with clinical data related to epilepsy. Depression level was evaluated by the Hamilton Depression Rating Scale-17 (HAMD-17), and quality of life was evaluated by the Quality of Life in Epilepsy-31 (QOLIE-31). Results Thirty-six patients with epilepsy suffered from depression (25.7%). Complex partial seizures (OR = 0.112) and number of seizure types (OR = 3.773) were found to be clinical risk factors for depression. Low scores for seizure worry (OR = 0.947) and social function (OR = 0.947) on the 通讯作者： Email： QOLIE-31 increased the probability of depression in patients with epilepsy. Conclusion At tertiary epilepsy centers such as ours in China, the preva